| Title (Click to Show All) || | Director || | Genre || | Manufacturer || | Type || | Discs || | Notes | |
| Spaceballs * | Mel Brooks | Comedy | Fox | Blu-Ray | 1 | The Mel Brooks Collection | |
| Starsky and Hutch | Todd Phillips | Comedy | Warner Brothers | DVD | 1 | ||
| State and Main | David Mamet | Comedy | New Line | DVD | 1 | ||
| Step Brothers | Adam McKay | Comedy | Columbia TriStar | DVD | 2 | ||
| Strange Brew | Dave Thomas, Rick Moranis | Comedy | Warner Brothers | DVD | 1 | ||
| Stripes | Ivan Reitman | Comedy | Columbia TriStar | DVD | 1 | Extended Cut, also includes theatrical cut | |
| Sullivan's Travels | Preston Sturges | Comedy | Criterion | DVD | 1 | ||
| Sullivan's Travels * | Preston Sturges | Comedy | Criterion | Blu-Ray | 1 | CC40 | |
| Superbad | Greg Mottola | Comedy | Columbia TriStar | DVD | 2 | ||
| Surf Nazis Must Die | Peter George | Comedy | Troma | DVD | 1 | ||
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